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Psoriasis pathology mechanism


Description Summary: Whole-genome expression profiling has been used to characterize molecular-level differences between psoriasis lesions and normal skin.

psoriasis pathology mechanism pikkelysömör fotó a testen és a kezelés

Pathway analysis, however, is complicated by the fact that expression profiles have been derived from bulk skin biopsies with RNA derived from multiple cell types. We identified differentially expressed genes, including 8 associated with psoriasis susceptibility psoriasis pathology mechanism.

psoriasis pathology mechanism a hasán vörös folt hólyagokkal

To facilitate pathway analysis, PP versus PN differences in gene expression were analyzed with respect to gene modules, each containing genes with a similar expression pattern in keratinocytes and epidermis. These DEMs were associated with regulatory axes involving cytokines e. We identified an interferon-induced DEM with genes encoding anti-viral proteins designated "STAT"which was activated in psoriatic epidermis but repressed following biologic therapy.

psoriasis pathology mechanism pikkelysömör kezelés a gyermekek véleménye

We analyzed a large patient cohort and developed a new approach for delineating epidermis-specific pathways and regulatory mechanisms that underlie altered gene expression in psoriasis.

Our findings highlight previously unrecognized "transcription circuits" that can provide targets for development of non-systemic therapies.